IERSD is located at Penteli, on Koufos hill, about 20 km north of the city of Athens. Certain activities are still located at the Thissio site, close to the Historical Centre of the city, on the hill of Nymphs, near Acropolis. There are also some offices in Omonoia square, in the center of Athens.

Only few offices of the IERSD are still hosted in the historical buildings at Thissio site of NOA, located on the small hill of Nymphs, overlooking the Acropolis.